International Journal of Scientific Research and Engineering Development

International Journal of Scientific Research and Engineering Development


( International Peer Reviewed Open Access Journal ) ISSN [ Online ] : 2581 - 7175

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Oral Cancer and Pathogenesis



   
International Journal of Scientific Research and Engineering Development (IJSRED)
Published Issue : Volume-3 Issue-4
Year of Publication : 2020
Unique Identification Number : IJSRED-V3I4P24
Authors : Shraddha Awasthi


MLA

Shraddha Awasthi "Oral Cancer and Pathogenesis" International Journal of Scientific Research and Engineering Development (IJSRED) Vol3-Issue4 | 151-159.



Abstract :

Oral cancer is one of the most common cancer. it constitutes a major health problem mainly in developing countries. The habit of chewing betel nut leaves rolled with lime and tobacco, a mixture known as pan, results in extended contact of the carcinogen with the buccal mucosa, which is thought to be the principal cause of Oral cancer (OC) in India. Materials and methods The literature search was carried out in NCBI Pubmed database using keywords ‘‘oral squamous cell carcinoma’’, ‘‘risk factors’’, ‘‘pathogenesis’’ and ‘‘genetic alterations*’’. Some elementary information also obtained from textbook and medical university websites. Results There are Some risk factors have been well defined which is related with oral squamous cell carcinoma with substantial evidences. The enhancement of oral cancer is a multistep process including the accumulation and consideration of genetic and epigenetic alterations in key regulatory genes. Tentative pathological studies of oral cancer in animal models and direct molecular genetic analysis of oral cancer subjects in recent times have exposed a significant amount of knowledge of some specific genetic alterations or other genetic mechanisms involved in beginning and subsequent progression.Conclusion Considering known risk factors, oral cancer appears to be to a certain level, a preventable disease. Recentgrowth of molecular picture of patho-progression and molecular genetic tools opens the path for easier diagnosis, better prognostication and efficient therapeutic management.



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