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A Review on Tacrolimus : A Potent Immunosuppressive Agent

	International Journal of Scientific Research and Engineering Development (IJSRED)	Full Text:
	Published Issue : Volume-3 Issue-6
	Year of Publication : 2020
	Unique Identification Number : IJSRED-V3I6P63
	Authors : Mullaicharam, Khalid Al Balushi, Korlapati Venkateswara Rao, Alka Ahuja, Muna Al Dalai, Majed M Abukhader, Nirmala Amaresh, Sushma Pole
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Abstract :

Tacrolimus (FK 506) is a highly potent immunosuppressive agent and has proven activity in both in-vivo and in-vitro experiments. Tacrolimus is also a calcineurin inhibitor. Because of its poor solubility, Tacrolimus has a large inter /intra-patient variability in its pharmacokinetics profile. To improve oral delivery of this agent, there are several formulation approaches such as oily solution, solid dispersions, complexation with cyclodextrins, liposomes etc. that have been investigated. Tacrolimus has been prescribed for liver, intestinal, lung and heart transplant recipients and can be used to manage severe autoimmune conditions, such as atopic dermatitis and rheumatoid arthritis.Tacrolimus is used most frequently in comparison to other immunosuppressant because it offers better safety profile with increased long-term survival in patients.