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Evaluation of the Acute Effect of Nishamalaki Churna in the Management of Blood Glucose Level in Diabetes Mellitus Type 2

	International Journal of Scientific Research and Engineering Development (IJSRED)	Full Text:
	Published Issue : Volume-4 Issue-1
	Year of Publication : 2021
	Unique Identification Number : IJSRED-V4I1P104
	Authors :T.K.G.Punchihewa, R.V.Ekneligoda, P.P.Uyanege
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Abstract :

Diabetes mellitus refers to the group of diseases that lead to high blood glucose levels due to defects in either insulin secretion or insulin action. It is usually irreversible and, although patients can have a reasonably normal lifestyle, its late complications result in reduced life expectancy and major health costs. Diabetes mellitus is referred to Madhumeha, one of the types of Prameharoga. Since no known scientific study has been conducted to evaluate the acute effect of Nishamalakichurna which is made by using Curcuma longa and Emblicaofficinalis in equal proportion in the management of blood glucose level. In clinical study Ten were selected and instructed same for dietary habits, lifestyle and administration of antidiabetic drugs for two weeks and specially advised to have same dinner before the blood test and to fasting for 10 hours. After first week 5g of Nishamalakichurna diluted in 100ml of Luke warm water was given to the patient while blood drawing for Fasting Blood Sugar (FBS) test. Then Oral Glucose Tolerance Test (OGTT) was done. In their second visit 100ml of Luke warm water was given on behalf of the drug and repeated same procedure. The levels of FBS and OGTT were separately measured and average levels are considered. Also a non-parametric test called “Wilcoxon Sign Rank Test” was applied for testing the difference between two dependent samples. Since p-values are not less than 0.1, during the period of one and half hours, the drug NishamalakiChurna has shown a significant effectiveness at 10% significant level. The effectiveness of the drug has not been statistically significant for the remaining periods of times. So it can be concluded that the acute action of Nishamalakichurnais not effective for reduce blood glucose level for the remaining period of times. Even though there are strong evidence for effectiveness of Nishamalakichurna in the management of Diabetes mellitus. Therefore for a perfect conclusion the study sample should be expand under more numbers of patients and the study setting should be IPD (inpatient department) of the hospital.