International Journal of Scientific Research and Engineering Development

Mesoporous silica nanoparticles and doxorubicin hydrochloride solutions were prepared at concentrations of 0.01, 0.03, 0.05, 0.07, and 0.09 mg/ml to study their effects on gastric cancer cells. The samples were then applied to cultured gastric cancer cells to evaluate the performance of the doxorubicin nanomedicine.The study uses tools like electron microscopes and spectrophotometers to analyze mesoporous silica nanoparticles loaded with doxorubicin, examining their structure, drug release, and effects on gastric cancer cells.Using various instruments, assess mesoporous silica nanoparticles loaded with doxorubicin hydrochloride for their shape, surface, pore characteristics, drug release, adsorption, loading, encapsulation, and effects on gastric cancer cells.The test results indicate that mesoporous silica nanoparticles are effective or drug delivery. They have a high capacity to load and encapsulate drugs, and they release drugs in a controlled manner. In particular, their effectiveness increases in slightly acidic environments, like those found at tumor sites, aiding in drug release.Mesoporous silica nanoparticles have been used for drug delivery, achieving a drug loading of around 55% after being subjected to ultrafiltration three times. The encapsulation efficiency of these nanoparticles is over 90%. When the concentration of the drug-loaded nanoparticles is increased, it results in a gradual decrease in the survival rate of gastric cancer cells.Doxorubicin nanomedicine can help stop the growth of gastric cancer cells and aid in treating gastric cancer.