International Journal of Scientific Research and Engineering Development

Despite wide interest in nucleoside derivatives for treating viruses, cancer, and microbial infections, traditional synthesis methods rely on severe conditions, harmful solvents, yet pose environmental and health risks. Because of such drawbacks, recent efforts shift toward eco-friendly strategies - this work reviews possible green pathways using existing data, theoretical frameworks, still prioritizes low-impact, affordable techniques. Though challenges remain, safer alternatives emerge through careful reagent selection, energy-efficient processes, thus aligning chemistry with long-term ecological balance. Looking at how green chemistry shows up in making nucleosides, this work reviews choices like safer solvents, gentle reaction settings, lower power needs, while cutting down waste. Ways to alter molecular structure come into view alongside tools often seen in papers - Fourier Transform Infrared Spectroscopy (FT-IR), Nuclear Magnetic Resonance (¹H and ¹³C NMR), Mass Spectrometry - to help grasp how these modified nucleosides take shape and get checked. Looking at past work, greener ways to build nucleoside compounds might lead to useful treatments, especially against infections and cancer. Even though this report does not include lab tests or new experiments, earlier results show eco-friendly techniques could replace traditional ones while keeping strong medical value. What stands out is how these methods maintain effectiveness without relying on harsh chemicals. Some researchers found simpler routes using less energy still yield active molecules. One key point lies in reduced waste during production. Another advantage appears in safer byproducts. While full testing remains outside this scope, trends across papers support a shift toward sustainable design. Earlier data back the idea that gentle conditions do not weaken performance. Progress here ties closely to solvent choices and reaction efficiency. Still, outcomes depend heavily on molecular structure. Not every approach works equally well across cases. Yet overall patterns favor environmentally considerate pathways. This work underscores how eco-friendly methods in chemical creation matter greatly within medicine development. Green strategies for crafting nucleoside variations could guide upcoming paths in identifying new treatments - alongside testing them rigorously. The findings point toward long-term viability when sustainability shapes lab practices.

Dr.Sarika Arora, Surojit Sanyal, Dr.Vaibhav Shah,"Green Synthesis of Novel Nucleoside Derivatives with Therapeutic Potential" International Journal of Scientific Research and Engineering Development, V9(1): Page(1297-1303) Jan-Feb 2026. ISSN: 2581-7175. www.ijsred.com. Published by Scientific and Academic Research Publishing.